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Appl Environ Microbiol 87(23):e0163621

4 GGG specifically inhibits migration of P2RY8-expressing WEHI-231 cells

Exercise and Physical Performance Research Age-Related Physical Decline Investigations in aging mice demonstrated that MOTS-c treatment significantly improved physical capacity across multiple age groups: Enhanced running endurance in young (2-month), middle-aged (12-month), and old (22-month) mice Improved grip strength and rotarod performance in aged animals Late-life intermittent treatment (beginning at 23.5 months) increased healthspan metrics Reversal of age-dependent decline in mitochondrial function Notably, human studies confirmed that exercise induces endogenous MOTS-c expression in both skeletal muscle tissue and circulation, suggesting evolutionary conservation of exercise-responsive signaling

Circulation 100 : 576578 Stary HC, Chandler AB, Dinsmore RE, Fuster V, Glagov S, Insull Jr W, Rosenfeld ME, Schwartz CJ, Wagner WD and Wissler RW (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis

It has been shown that in human breast tissue, high levels of ROS are activated and transported by basoluminal precursors, which are direct precursors of basal-like breast cancer [327,328]