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Thrombospondin-2 as a diagnostic biomarker for distal cholangiocarcinoma and pancreatic ductal adenocarcinoma

Age-related peptide decline also plays a role, as levels of endogenous growth factors and repair peptides decrease with aging

Moreover, with the increase in the CaOx concentration, the relative expres-sion levels of ferroptosis-related signaling pathway proteins (p53, ACSL4, TF, and TRC) significantly increased, while the relative expression levels of XCT and GPX4 decreased

Across these contexts, N1-type neutrophils are consistently defined by a proinflammatory program that amplifies inflammatory cascades, disrupts tissue homeostasis, and drives multi-organ dysfunction

Additionally, pathologies like cancer, diabetes mellitus, cardiovascular diseases, and chronic kidney disease can cause an increase in oxidative stress