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A broader range of doses and the administration frequency should be assessed in both the preclinical and clinical studies of 7nAChR ligands

But if your symptoms persist, its a good idea to talk with your doctor

Community reports from the first week cluster around "nothing dramatic," sometimes with mild gastrointestinal adjustment at higher oral doses or the characteristic fishy odor that signals trimethylamine production

JCI Insight 5, (2020)

However, this dosing schedule does not have a strong evidence base, and many individuals with PA / B 12 deficiency / PA report requiring more frequent injections for adequate symptom relief [3]