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Taken together, these effects may explain the differences in disease control rates in this trial and offer insight as to the appropriate interval between different anti-CD38 antibody therapies

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Furthermore, excessive accumulation of NADH in conjunction with reduced NAD + availability can inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in the glycolytic pathway, leading to glucose shunting to the glycolytic branch pathway (Yan et al., 2016