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Also, under United States law, products sold as dietary supplements cannot have claims that the supplement treats or prevents any disease or condition, and the advertising material must contain a statement that the health claims are not approved by the FDA

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Mild redness (less than 3 cm, fading within hours): Cold compress for 10 minutes No additional treatment needed Monitor for expansion Moderate redness (3 to 5 cm, lasting 1 to 3 days): Cold compress every 2 to 3 hours for first 24 hours Hydrocortisone 1% twice daily Ibuprofen 200 to 400mg if uncomfortable Significant redness (more than 5 cm, warm to touch, lasting more than 3 days): Cold compress protocol as above Hydrocortisone 1% twice daily Oral antihistamine daily Ibuprofen 400mg every 6 hours If not improving by day 5, contact healthcare provider Tracking the size of redness helps determine whether a reaction is improving or worsening

Under medical supervision

After homogenization, the supernatant was centrifuged and measured with a sensitive and specific ELISA according to the manufacturers instructions for TNF-, IL-10 and IL-1 (RayBiotech, Norcross, GA, USA)