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doi: 10.1111/1574-6968.12142

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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

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Their higher energy content not only supports exercise performance and recovery but also contributes to enhanced satiety, perceived vitality, and consumer acceptancefactors that are increasingly recognized as determinants of long-term adherence to supplementation strategies