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However, due to staggered or inadvertent APAP overuse, cellular GSH can be depleted and the GSH conjugation pathway can be saturated, resulting in NAPQI accumulation, leading to increased protein binding (Mitchell et al., 1973b)

91 Thus, GSH can drive efflux-mediated resistance by both enabling antibiotic efflux and modulating the redox state of efflux pump regulators

5) AD AD, the most common neurodegenerative disorder worldwide, is characterized by typical neuropathological features, including extracellular A plaques and intracellular neurofibrillary tangles composed of the hyperphosphorylated Tau-protein [432]

Fowelin, J., Attvall, S., Lager, I

Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects