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The functional significance of ERK1/2 activation by BPC-157 is further supported by inhibitor studies: when the ERK pathway is pharmacologically blocked, BPC-157s pro-migratory and pro-angiogenic effects are abolished, underscoring the pathways critical role in mediating cellular activity [55]

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Risk factors include the speed and magnitude of weight loss, pre-existing nutritional deficiencies, age, sex (women are more commonly affected), and individual genetic susceptibility