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This can be a problem when folate is limited.[ref][ref][ref] One copy of the C677T variant reduces enzyme function by about 35-40%
GST participates in the detoxification of xenobiotic compounds by catalyzing their conjugation with GSH to form nontoxic products that are often eliminated by cells through the multidrug resistance protein MRP1 (73)
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Lastly, p62 is a protein that binds to ubiquitinated protein aggregates, cellular debris, bacteria, and viruses, targeting them for the autophagosome
