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Science 245:10661073

Shaking also creates foam, which dramatically increases the surface area exposed to air and can physically denature proteins and larger peptides through the mechanical forces at bubble interfaces

This phenomenon has a hepatoprotective effect

Dietary supplements are marketed in forms such as tablets, capsules, soft gels, gel caps, powders, and liquids. A range of anabolic steroids are also on the list, as well as substances that are more commonly considered recreational drugs

Significant pathological changes, including the formation of hepatocellular carcinoma (HCC), occurred in hepatocytes (47)
