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Lipid peroxidation is central to membrane disruption: oxidation of polyunsaturated fatty acids (e.g., arachidonic acid, docosahexaenoic acid) generates lipid peroxides (e.g., 4-HNE), which crosslink with amino groups of membrane phospholipids, destabilizing the lipid bilayer and increasing permeability

Effects of myricetin, an anticancer compound, on the bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats

doi: 10.1038/oby.2010.54 23

The researchers then treated these aged human neurons with the Pinealon (EDR) peptide

CNS Neurol Disord Drug Targets (2017) 16(10):10908
