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Given once daily on days 1 and 10, and three times daily from days 49, all adverse events were mild and selfresolving, showing good safety [259]

The upper dermis (layer of the skin below the epidermis) may have some microscopic inflammation called mild superficial perivascular lymphocytic inflammatory changes

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In addition to immune-targeted nanoformulations, repurposed anti-inflammatory drugs can be reformulated at the nanoscale to enhance cytotoxicity and modulate the tumor microenvironment (87, 88)

There are few studies on neurovascular coupling in cSVD patients and only those using a visual or motor stimulus and functional MRI to measure CBF changes will be reviewed herein, since those employing cognitive tasks add another layer of complexity to interpret the data (507)