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Findings suggested that AOD-9604 retained lipolytic activity in the absence of functional 3-AR, implicating additional receptor-independent mechanisms, potentially involving better-supported energy expenditure and fat oxidation pathways, in the peptides metabolic implications

HUBERMAN: In order to find out the lethal dose of something, as you can imagine, unfortunately, the way these studies are done is they give animals more and more, that is higher and higher doses of a given compound, find out at what point about 50% of the population of those animals starts to die, and then that's the so-called LD50, or at least that's one crude way of describing it

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Katre P, Bhat D, Lubree H, Otiv S, Joshi S, Joglekar C, Rush E, Yajnik C, et al
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