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also found the imidazo[1,2- b ]pyridazine scaffold of 89 , and modified substituents in the 3-position of this type skeleton through the introduction of an electron-withdrawing group and hydrophobic substituents to the amide nitrogen to improve permeability and affinity for IKK

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Moreover, siRNA knockdown of p97/VCP in HEK293 cells significantly increased the amount of ATP7A T994I retained in the TGN, directly implicating the aberrant interaction between these two proteins in the mislocalization of ATP7A T994I at the plasma membrane (Yi et al., 2012)

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H.MontesinosP.PfeilstockerM.PapayannidisC.et al (2024)

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