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A second line of antioxidant defense involves exogenous low-molecular-weight antioxidants derived from the diet, such as vitamin C, vitamin E, carotenoids, flavonoids, and other antioxidants

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In hTYR, the hydroxylphenyl group of Arbutin_c, which originally coordinated with CuA, shifts and instead coordinates with CuB during the simulation (Fig

Notably, these mechanisms work synergistically with existing therapies for FAO disorders