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Drug Discovery 2021, 20 (5), 362 383, DOI: 10.1038/s41573-021-00139-y142Strategies for delivering therapeutics across the blood-brain barrierTerstappen, Georg C

Selegiline/Modafinil (Focus/Energy Aids) Mechanism: Stimulant/activating agents alter arousal and wakefulness circuits

Some people experience headaches during the first week or two at this dose level, which typically resolve as the body adjusts

10.1155/2017/2984826 173 ZhuX.-J.LinY.-J.ChenW.WangY.-H.QiuL.-Q.CaiC.-X.et al (2016)

The effects are accumulating even if you can't see them yet
