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2.2.3 Effects on Non-Epithelial Cells Multiple non-epithelial cells in the mammary environment have been reported to express PRLR (72, 73)

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[1] The effects were even more pronounced in aged animals

A follow-up study involving 13,440 participants demonstrated that dietary betaine intake was not associated with T2DM (61)

Once stabilized, HIF- translocates to the nucleus, dimerizes with HIF-1/Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT), and forms a HIF transcription factor to promote cellular pathways influencing proliferation and malignant progression (39, 156158, 164)