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In an RCT including 72 patients with HT, treatment with Fuzheng-Jiedu-Xiaoying decoction (200 mL twice daily for 12 weeks) was compared to selenium supplementation (200 g twice daily for 12 weeks) and was found to significantly improve the clinical symptoms, reduce serum levels of thyroid antibodies, increase the ratio of Treg cells, reduce the ratio of Th17 cells, and reduce the incidence of hypothyroidism, with no observed allergic reactions or other adverse effects on the liver, kidney, or gut [63]

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