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(2022) found similar embryonic effects and fetal malformations when escitalopram was administered in mice during pregnancy, including changes in the number of reinstatements, post-implantation loss, reduced fetal survival, reduced kidney size, supra-occipital ossification insufficiency, and the absence of ribs and phalanges

This was attributed to the decreased infiltration of tumor-associated macrophages within the tumor microenvironment that produces matrix metalloprotease 9 (MMP-9) which is well documented to play a crucial role in the process of angiogenesis [129]

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But due to safety concerns, the FDA removed a group of them from the list that compounding pharmacies could make