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High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemicals bio-activation with regards hepatotoxicity
Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice
Clinical studies have confirmed that AOD-9604 does not stimulate IGF-1 production in any biological system tested, including human clinical trials monitoring serum IGF-1 levels over 24-week treatment periods
Copper depletion modulates VEGF and cytokine expression
P values less than 0.05 were considered to indicate statistical significance
