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2.2.5 Crosstalk of signaling pathways associated with PI3K/Akt Multiple constituents of ESCM can act on the upstream or downstream pathways of PI3K/Akt, ultimately intervening in the PI3K/Akt pathway through crosstalk effects

Therefore, increasing free radicals production and the reducing antioxidant defense system cause these radicals accumulation in the cell, which ultimately affects the cell activity, leading to membrane channels' formation in mitochondria and activation of caspases 9 and 3