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Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress

10.1016/0378-4347(87)80104-4 129 ShibataK.KawadaT.IwaiK

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Pruritus: Itching is another form of skin reaction when taking vitamin B-complex supplements

1948 Sep;33(9):1123-32