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Therefore, developing and validating biomarkers that directly indicate neuronal ferroptosissuch as specific oxidized phospholipid profiles, ferroptosis-related proteins (e.g., released HMGB1, modified GPX4), or their metabolic fragmentsis crucial for enhancing clinical diagnostic and therapeutic monitoring capabilities

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Sometimes its also about patterns

This represents a distinct analytical advantage, as significant sample dilution helps minimize matrix interference

Vitamin C and E levels were found to be significantly lower in patients with COVID-19 compared to healthy controls, while vitamin A showed only a slight decrease in patients with COVID-19