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Acknowledgements We would like to thank Dr Dirk Bohmann (University of Rochester, USA) for kindly providing the HA-Ub plasmid and Dr Zhijian Chen (University of Texas Southwestern Medical Center, USA) for the HA-Ub-K48R and HA-Ub-K63R mutant constructs

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Interactions between elevated intracellular calcium level and inflammation are suggested among the causes of the prominent oxidative stress