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To best address this, the physician should explore the patient's goals for the visit by asking, "Help me to understand what you are hoping I can do for you today." When a patient repeatedly seeks medical care but declines recommended treatments, physicians must avoid expressing frustration and instead focus on understanding the patient's underlying motivations

Porcelli, M., Fusco, S., Inizio, T., Zappia, V

M.KarpinskiS.JimnezA.ClearyS

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Although we have shown a strong association between upstream p38 MAPK inhibition and downstream Nrf2 activation coupled with functional improvementand this regulatory relationship is consistent with established mechanismsdirect experimental confirmation of Nrf2s necessity in this pathway, such as through the use of Nrf2-specific inhibitors or genetic knockout approaches, will be required in future work