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Capable of producing considerable damage, the superoxide anion is the preferred weapon of the human immune system

Some drugs can modulate the FoxO transcription factor activity (Table 2)

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The epigenetic regulatory roles of curcumin include the inhibition of DNA methyltransferases (DNMTs), regulation of histone modifications via the regulation of histone acetyltransferases (HATs) and histone deacetylases (HDACs), regulation of microRNAs (miRNA), action as a DNA binding agent and interaction with transcription factors

PMID 27701665