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207,208 In cancers, these pathways become dysregulated, often through ligand overexpression or mutations in key components (e.g., PTCH1 or SMO, in Hedgehog-driven malignancies such as basal cell carcinoma 209 and medulloblastoma 210 )
For the rest, error bars represent SD, ** P 0.01 based on a two-tailed unpaired t -test
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