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The Use of Methadone and Ketamine for Intraoperative Pain Management in Cardiac Surgery: A Retrospective Cohort Study J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2024.11.019 Christopher J Boos, Aung Hein, Ahmed Khattab Ambulatory arterial stiffness index, mortality, and adverse cardiovascular outcomes

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This positive signal is further corroborated by another recent umbrella review, which highlighted that Coenzyme Q10 consistently demonstrates beneficial effects on cardiac function and clinical outcomes across meta-analyses ( 3.3 Emerging data in heart failure with preserved ejection fraction and endothelial function A 2022 phase II, double-blind, randomized trial in patients with preserved ejection fraction (HFpEF) reported that ubiquinol (600 mg/day), alone or combined with D-ribose, modestly enhanced LVEF and alleviated symptom burden, though exercise capacity improvements were inconsistent ( 3.4 Statin-associated myopathy Although there is mechanistic plausibility for Coenzyme Q10 in alleviating SAMS, a 2021 meta-analysis identified no significant improvements in myalgia or creatine kinase levels relative to placebo (Wei et al., 2022)

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