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DNA damage was assessed by measuring the levels of 8-oxo-7,8-dihydroguanine (8-oxoG), representing oxidatively damaged purines ( , the levels of 8-oxoG were reduced by 26.2% compared to baseline and by 35.4% compared to placebo

Front Cell Neurosci:14 Nickols HH, Conn PJ (2014) Development of allosteric modulators of GPCRs for treatment of CNS disorders

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The much lower IC 50 values of P-CyPt than CDDP or preformed Pt IV NPs toward HeLa cells matched that of a significantly higher uptake of Pt(II) drug in P-CyPt - treated HeLa cells than that in CDDP- or preformed Pt IV NPs-treated HeLa cells (Fig