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In contrast to the heme of hemoglobin and myoglobin, the heme iron of all cytochromes participate in the cyclic redox reactions of electron transport, alternating between the oxidized (Fe 3+ ) and reduced (Fe 2+ ) forms
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Thats why we strive to maintain tight tolerances for peptide content, moisture, and residual solvents, so you can trust the integrity of your experiments

Comparison of Simple Potential Functions for Simulating Liquid Water