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Y., Tyagi, A

Br J Sports Med 51:636639

The administration of EGCG to the KYSE 510 esophageal cancer cell line, for durations spanning from 12 to 144 h, resulted in the hypermethylation of p16INK4a, RAR, MGMT and hMLH1 to be reversed in a manner that was dependent on time and concentration (29)

In support of glycolysis and the PPP competing for glucose 6-phosphate, in bacteria, knocking out the gene encoding the upper glycolytic enzyme glucose-6-phosphate isomerase redirects carbon flux to the PPP 39 , and, in yeast, reducing the activity of triosephosphate isomerase (TPI) results in increased NADPH formation in the PPP and increased oxidant tolerance 6

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