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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Muteeb G., Rehman M.T., Shahwan M., Aatif M

10.1007/s10439-016-1612-8 169 ZhaoG.ZhangX.LuT

Figure 6.7 A large myelinated nerve fiber in layer 4 of area 46 in a 25 year old monkey
It has also been shown to lower blood sugar levels by enhancing insulin sensitivity in nearby tissues and increasing insulin secretion [50]