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Accordingly, IGF-IR inhibition can enhance the efficacy of castration and abiraterone on prostate cancer [114, 115]

Since NO is a key molecule controlling vasodilation, zinc deficiency-caused stress and reduction of NO are considered to play an important role in the pathogenesis of atherosclerosis and diabetic complications 28 , which will be discussed in detail in the following sections

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Therefore, we examined the possibility that Y-56 restrains the AKT and EKR pathways by targeting IGF-1R