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Enzyme replacement therapy for hypophosphatasia has shown promising results in human clinical trials, reducing mortality in hypophosphatasia and improving chondromalacia, lung function and exercise milestones in these patients [44]
In addition to MNAM and NNMTi, three new NAM analog inhibitors were reported for the treatment of MetS-related disorders in animal models: JBSNF-000088 ( JBSNF-000265 (Ruf et al., 2018), and JBSNF-000028 (Ruf et al., 2022)
doi: 10.1080/14728214.2017.1269744
Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11845-023-03602-4
