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Endothelial dysfunction can disrupt homeostasis, increasing the risk of atherosclerotic disease and hypertension

High iron levels are a risk factor for type 2 diabetes mellitus (T2DM) and impacts the cardinal features: such as increased insulin resistance, decreased insulin secretion and elevated hepatic gluconeogenesis

In the bloodstream, chylomicrons acquire apoC-II and apoE from plasma HDL

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In particular, increased lipid peroxidation is an important signal for triggering ferroptosis, an iron-dependent form of cell death that was first identified in mutated RAS cancer cells (Xie et al., 2016