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Crosstalk with RNS/RSS and Iron section addresses crosstalk with RNS/RSS and iron ( NO/ONOO chemistry, persulfidation, Fenton/ferroptosis) and emphasizes microdomains and contact-site biology (MAMs, peroxisomemitochondria, mitochondrialysosome)

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In the studies reviewed, two widely used hepatocellular models were employed to assess hepatotoxicity of environmental contaminants: the hepatocellular carcinoma line HepG2 and the bipotent progenitor line HepaRG

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