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Methods HCECs cultured in iso-osmolar medium (312mOsM) were switched to hyperosmotic media with or without prior incubation with 220mM of L-carnitine, erythritol or betaine for different time periods

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In agreement with the above, altered energy metabolism in the brain correlates with increased ER stress, impaired protein degradation pathways, altered proteostasis, and the accumulation of toxic protein products in the brain (393, 394)

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