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The large phase 3 EVOKE trials in people who already had mild cognitive impairment or mild Alzheimers did not slow the disease, but the observational signal for prevention is strong, with real-world data from more than a million patients showing that semaglutide users have a 40 to 70 percent lower risk of a first Alzheimers diagnosis than users of other diabetes drugs

Sampling from AD patients utilizing the tape stripping method has revealed increased levels of PC in the stratum corneum, a phenomenon similarly observed in patients with psoriasis (97)

Awuchi CG et al

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