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Trimethylamine-N-oxide (TMAO) predicts short- and long-term mortality and poor neurological outcome in out-of-hospital cardiac arrest patients

Robert Koeth Zeneng Wang Bruce Levison Stanley Hazen Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO)

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Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice
