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The disease affects the brain, spinal cord, heart, muscles, and beta () cells of the pancreas, thereby characterising the disease by progressive neurodegeneration, musculoskeletal deformities, diabetes mellitus and hypertrophic cardiomyopathy ( FXN gene ( FXN gene codes for a very important mitochondrial protein called frataxin (Weng et al., 2020)
Kim JW, Seung H, Kwon KJ, Ko MJ, Lee EJ, Oh HA, et al
Under adverse environmental conditions, excessive amounts of ROS are formed, which leads to oxidative stress
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doi:10.1358/dnp.2008.21.4.1213351
