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L-carnitine stands out because its basic job in the body is easy to explain: it helps shuttle long-chain fatty acids into mitochondria, the tiny energy factories in every cell

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects

A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

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