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Deficiencies in vitamin B12 can lead to symptoms like headaches, fatigue, irritability, depression, anxiety, numbness and tingling in extremities, digestive problems and even nerve damage and cognitive issues

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At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )

Metabolic tracer studies in humans demonstrate that adipose tissue derived FAs account for the majority of hepatic TAGs in FLD patients, suggesting that dysregulation of adipocyte lipolysis is a major mechanism of diet-induced FLD (203) (Figure 5)

The root cause of a vitamin B12 deficiency can be one of several things