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There has been a dramatic rise in reports detailing complications long after bioalkylimide placement

The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

Science 209:976983, 1980 Heiling M, Murison R: Intracerebroventricular neuropeptide Y protects against stress-induced gastric lesions in rat

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However, using methylcobalamin, cyanocobalamin, or other B12 supplements may pose the following risks: Cobalt Allergy People with a cobalt allergy or sensitivity should talk with a healthcare provider before using vitamin B12 supplements