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Although several studies showed that targeting pericytes and ECs leads to impaired tumor growth and improved efficacy to anti-angiogenic agents, data negating the potentiation of treatment outcome with dual blockade exists (275)

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The absorbance was measured at 450 nm using an enzyme marker (BioTek, Gen 5), and the growth rate of cells was calculated as follows: where A blank is the absorbance of the wells without cells, and A control and A test are the absorbances of the control and treated cells, respectively