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Most people are deficient in vitamin B12, especially those on plant-based diets

The accumulation of misfolded protein in the endoplasmic reticulum (ER) leads to ER dysfunction, which is known as ER stress ( 12 regulated ER homeostasis ( 12 deficiency activated ER stress pathways by increasing the phosphorylation of PERK and IRE1 and the expression of ATF6 ( 12 could promote nerve regeneration after TBI by regulating ER stress

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Whether AOD-9604 at research doses causes clinically meaningful receptor downregulation in humans is unknown