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Apr 26 2021;10(9)doi:10.3390/jcm10091876

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NOX1 negatively modulates fibulin-5 in vascular smooth muscle cells to affect aortic dissection

New research shows GCN5L is key to how cells respond to nutrient stress by actively controlling acetylation in the energy-sensing network ( In the amino acid starvation model, GCN5L controls mTORC1 signaling mainly by adjusting acetylation of the K99 site on RagC GTPase, weakening its binding affinity with the Ragulator complex and preventing mTORC1 from localizing to lysosomes

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