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Investigations in a zebrafish model demonstrated that zebrafish ovaries in the Hg-exposed group revealed a reduction in the number of previtellogenic and early vitellogenic oocytes and atresia of the previtellogenic oocytes

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In the mouse experiment of this cohort study, the investigators found that knocking out Keap1 resulted in the expression of Nrf2 target genes (such as GSH and NQO1), which supplemented the consumption of GSH in the oxidative stress response (Mohs et al., 2021)

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In the presence of BDZs, GABA interneurons are inhibited and no longer control (i.e., inhibit) DA neurons in the VTA (a process known as disinhibition), which results in increased activity of VTAs DAergic neurons