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MDT-15/MED15 confers the regulation of the fatty acid metabolism through direct and specific binding to the activation domains of NHR-49 and SBP-1

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Among clinical variables (Supplementary Table 2), in univariable analysis obesity (Estimate: 50.59, 95 % CI: 20.99 to 80.20, P = 0.0012) and BMI (Estimate: 2.30, 95 % CI: 0.50 to 4.10, P = 0.0133) were both significantly associated with higher MOTS-c levels (263.6 53.1 vs 213.0 53.5 pg/mL, P = 0.001 vs