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doi: 10.1016/j.trsl.2012.10.006

The upregulation of PD-L1 may be an adaptive response to excessive immune activation

Cholesterol levels influence nuclear hormone receptor activity such as of the PPAR homolog NHR-49, which is involved in the regulation of FA synthesis

However, for a very tall protein with average height 40 nm and antibody binding at sites higher than 20 nm, the offset becomes appreciably smaller than the antibody binding to terminal protein domains at equivalent heights

Protein-protein interactions (PPI) are involved in all cellular processes and many represent attractive therapeutic targets