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Meanwhile, mitochondrial damage induces autophagy, and the autophagic system binds to ferritin via NCOA4-mediated selective autophagy, accelerating the disintegration of iron storage pools, releasing a large amount of free divalent iron ions, inducing the Fenton reaction, and ultimately leading to ferroptosis [53]

J Exp Clin Cancer Res (2019) 38(1):223

But most of the affected study holds up

And for some, it can cause numbness in this region of the leg

The good news is, there are ways to support methylation and detoxification, even if you have a mutation.* Supplement with L-Methylfolate Instead of relying on your MTHFR enzyme to make it, you can take supplementary L-methylfolate which is pre-methylated or active folate that bypasses the need for MTHFR activity.* Support Cofactors Methylation doesnt run on folate alone [8]